N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

Base Information

Chemical Name:N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide
CAS No.:1427596-35-7
Molecular Formula:C₁₆H₁₇BrF₂N₆O
Molecular Weight:427.251
Hs Code.:

Synonyms:N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

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Chemical Property of N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

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Technology Process of N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

There total 1 articles about N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: N-[(3-aminopyrrolidin-3-yl)methyl]-2,4-difluorobenzamide dihydrochloride

: 663193-80-4
5-bromo-6-chloro-pyrimidin-4-ylamine

: 1427596-35-7
N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 60 ℃;

Reference yield: 61.0%

: 1427596-35-7
N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

: 1765-93-1
4-fluoroboronic acid

: 1427596-39-1
N-{3-amino-1-[6-amino-5-(4-fluorophenyl)pyrimidin-4-yl]pyrrolidin-3-ylmethyl}-2,4-difluorobenzamide

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1427596-35-7
N-[3-amino-1-(6-amino-5-bromopyrimidin-4-yl)pyrrolidin-3-ylmethyl]-2,4-difluorobenzamide

: 1765-93-1
4-fluoroboronic acid

: 1427596-85-7
N-{(R)-3-amino-1-[6-amino-5-(4-fluorophenyl)pyrimidin-4-yl]pyrrolidin-3-ylmethyl}-2,4-difluorobenzamide

: 1427596-86-8
N-{(S)-3-amino-1-[6-amino-5-(4-fluorophenyl)pyrimidin-4-yl]pyrrolidin-3-ylmethyl}-2,4-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate / 1,4-dioxane; water / 0.5 h / 100 °C / Microwave irradiation

2: Resolution of racemate

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water;