4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal

Base Information

• Chemical Name: 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal
• CAS No.: 503000-49-5
• Molecular Formula: C₂₇H₃₆O₂Si
• Molecular Weight: 420.667
• Mol file: 503000-49-5.mol

Synonyms:4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal

Chemical Property of 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal

There total 9 articles about 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-tert-butyldiphenylsilyloxy-4,4-divinyl-1-heptanol (503000-28-0) → 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal (503000-49-5)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ol034020s

Reference yield:

1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene (503000-47-3) → 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal (503000-49-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / H₂O₂ / tetrahydrofuran / 1 h / 20 °C

2: 100 percent / aq. HCl / ethanol / 2 h / 20 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; oxalyl dichloride; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/ol034020s

Reference yield:

4-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylbutanamide (215251-69-7) → 4-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-vinyl-hex-5-enal (503000-49-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 63 percent / t-BuLi / tetrahydrofuran; pentane / -78 - 20 °C

2: 96 percent / NaH / 1,2-dimethoxy-ethane; various solvent(s) / 6 h / Heating

3: 99 percent / DIBAL-H / tetrahydrofuran; hexane / 0.5 h / 0 °C

4: 81 percent / Hg(OAc)2 / 24 h / Heating

5: 81 percent / triisobutylaluminum / CH₂Cl₂; hexane / 1 h / 20 °C

6: 14.35 g / n-Bu₃P / tetrahydrofuran / 14 h / 20 °C

7: 91 percent / H₂O₂ / tetrahydrofuran / 1 h / 20 °C

8: 100 percent / aq. HCl / ethanol / 2 h / 20 °C

9: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; oxalyl dichloride; tributylphosphine; mercury(II) diacetate; dihydrogen peroxide; tert.-butyl lithium; triisobutylaluminum; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; pentane; 2: Horner-Emmons reaction;

DOI:10.1021/ol034020s

upstream raw materials:

7-tert-butyldiphenylsilyloxy-4,4-divinyl-1-heptanol

1-[3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-(tert-butyl-diphenyl-silanyloxy)-3-vinyl-hexylselanyl]-2-nitro-benzene

4-(tert-butyldiphenylsilyloxy)-N-methoxy-N-methylbutanamide

1-(tert-butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-heptan-4-one

Downstream raw materials:

C₂₇H₃₆SiO₂C₂H₄SiC₃H₈

(2S,3S)-9-tert-butyldiphenylsilyloxy-6,6-divinyl-2,3-epoxynonan-1-ol

(3S)-9-tert-butyldiphenylsilyloxy-6,6-divinyl-3-hydroxynona-1-en

9-tert-butyldiphenylsiloxy-6,6-divinylnona-2-en-1-ol