(2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Base Information

Chemical Name:(2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide
CAS No.:1240523-39-0
Molecular Formula:C₂₅H₂₄N₄OS
Molecular Weight:428.558
Hs Code.:

Synonyms:(2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

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Technology Process of (2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

There total 7 articles about (2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1240523-38-9
(S)-N-(3-bromophenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

: 579476-63-4
2-methylpyridine-4-boronic acid

: 1240523-39-0
(2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 3364-80-5
1,3-thiazole-4-carbaldehyde

: 1401206-87-8
C₂₁H₂₁N₃O

: 1240523-39-0
(2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.07.063

Reference yield:

: 1401206-80-1
C₂₆H₂₉N₃O₃

: 1240523-39-0
(2S)-N-(3-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(thiazol-4-ylmethylamino)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2012.07.063