ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

Base Information

Chemical Name:ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate
CAS No.:1393127-56-4
Molecular Formula:C₂₈H₃₁F₃N₂O₃
Molecular Weight:500.561
Hs Code.:

Synonyms:ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

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Chemical Property of ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

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Technology Process of ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

There total 7 articles about ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1393126-14-1
ethyl 4-((3,3-dimethylcyclobutyl)(hydroxy)methyl)benzoate

: 1393125-42-2
3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenol

: 1393127-56-4
ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

Guidance literature:: With tributylphosphine; di-isopropyl azodicarboxylate; In tetrahydrofuran; for 21h;

Reference yield:

: (4-bromo-2,6-dimethylphenyl)hydrazine hydrochloride

: 1393127-56-4
ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C

1.2: 5 h / 80 °C

2.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; tributylphosphine / tetrahydrofuran / 21 h

With tributylphosphine; di-isopropyl azodicarboxylate; sodium methylate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; n-heptane; water; ethyl acetate; 3.1: Mitsunobu reaction;

Reference yield:

: 24596-19-8
4-bromo-2,6-dimethylphenylamine

: 1393127-56-4
ethyl 4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

1.2: 16 h / 0 - 20 °C

2.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C

2.2: 5 h / 80 °C

3.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; tributylphosphine / tetrahydrofuran / 21 h

With hydrogenchloride; tributylphosphine; di-isopropyl azodicarboxylate; sodium methylate; potassium hydroxide; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; n-heptane; water; ethyl acetate; 4.1: Mitsunobu reaction;