Technology Process of (+/-)-3-(4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzamido)propanoic acid
There total 11 articles about (+/-)-3-(4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzamido)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 3-(4-((3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)(3,3-dimethylcyclobutyl)methyl)benzamido)propanoate;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 18h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
pH=3;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C
1.2: 5 h / 80 °C
2.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere
3.1: di-isopropyl azodicarboxylate; tributylphosphine / tetrahydrofuran / 21 h
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 8 h
4.2: pH 3
5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 1 h
6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C
6.2: pH 3
With
tributylphosphine; di-isopropyl azodicarboxylate; water; sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide;
tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; water; ethyl acetate;
3.1: Mitsunobu reaction;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C
1.2: 16 h / 0 - 20 °C
2.1: sodium methylate / tetrahydrofuran / 48 h / 0 - 20 °C
2.2: 5 h / 80 °C
3.1: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos / ethyl acetate; n-heptane; 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere
4.1: di-isopropyl azodicarboxylate; tributylphosphine / tetrahydrofuran / 21 h
5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 8 h
5.2: pH 3
6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 1 h
7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C
7.2: pH 3
With
hydrogenchloride; tributylphosphine; di-isopropyl azodicarboxylate; water; sodium methylate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; sodium nitrite;
tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos;
In
tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; water; ethyl acetate;
4.1: Mitsunobu reaction;
