methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate

Base Information

• Chemical Name: methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate
• CAS No.: 1582763-19-6
• Molecular Formula: C₂₇H₃₅NO₇
• Molecular Weight: 485.577

Synonyms:methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate

Chemical Property of methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate

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Technology Process of methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate

There total 3 articles about methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl vinyl ether (926-02-3) + (S,E)-2-(benzyloxy)-N-(1,4-dimethoxy-1,4-dioxobutan-2-ylidene)-1-phenylethanamine oxide → methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate (1582763-19-6) + methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate (1582763-18-5)

Guidance literature:

at 80 ℃; for 72h; Overall yield = 72 %; Sealed tube;

DOI:10.1021/ol500483t

Reference yield:

dimethyl acetylenedicarboxylate (762-42-5) → methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate (1582763-19-6) + methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate (1582763-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 0 - 20 °C

2: 72 h / 80 °C / Sealed tube

In dichloromethane;

DOI:10.1021/ol500483t

Reference yield:

(+)-(S)-N-hydroxy-2-(phenylmethoxy)-1-phenylethanamine (126927-02-4) → methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate (1582763-19-6) + methyl 2-((S)-2-(benzyloxy)-1-phenylethyl)-5-tert-butoxy-3-(2-methoxy-2-oxoethyl)isoxazolidine-3-carboxylate (1582763-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 4 h / 0 - 20 °C

2: 72 h / 80 °C / Sealed tube

In dichloromethane;

DOI:10.1021/ol500483t

upstream raw materials:

tert-butyl vinyl ether

dimethyl acetylenedicarboxylate

(+)-(S)-N-hydroxy-2-(phenylmethoxy)-1-phenylethanamine

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