N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

Base Information

Chemical Name:N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide
CAS No.:666752-56-3
Molecular Formula:C₁₅H₁₉ClN₄O₄S₂
Molecular Weight:418.925
Hs Code.:

Synonyms:N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

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Chemical Property of N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

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Technology Process of N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

There total 5 articles about N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 666752-57-4
2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

: 666752-56-3
N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

Guidance literature:: With sodium hydroxide; In methanol; water; at 80 ℃; for 1h;

Reference yield:

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 666752-56-3
N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol; water / 2 h

2.1: acetic acid; sodium nitrite / water / 0.17 h

3.1: acetic acid; zinc / ethanol / 0.08 h / Heating / reflux

4.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h

4.2: 1 h

5.1: sodium hydroxide / methanol; water / 1 h / 80 °C

With 1H-imidazole; sodium hydroxide; acetic acid; zinc; sodium nitrite; In methanol; DMF (N,N-dimethyl-formamide); ethanol; water;

Reference yield:

: 666752-53-0
2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-4-pyrimidinol

: 666752-56-3
N-(2-[(3-chlorobenzyl)thio]-4-hydroxy-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-pyrimidinyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; sodium nitrite / water / 0.17 h

2.1: acetic acid; zinc / ethanol / 0.08 h / Heating / reflux

3.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h

3.2: 1 h

4.1: sodium hydroxide / methanol; water / 1 h / 80 °C

With 1H-imidazole; sodium hydroxide; acetic acid; zinc; sodium nitrite; In methanol; DMF (N,N-dimethyl-formamide); ethanol; water;