2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Base Information

Chemical Name:2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate
CAS No.:666752-57-4
Molecular Formula:C₁₆H₂₁ClN₄O₆S₃
Molecular Weight:497.017
Hs Code.:

Synonyms:2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Suppliers and Price of 2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

There total 5 articles about 2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₇ClN₄O₂S

: 18162-48-6
tert-butyldimethylsilyl chloride

: 124-63-0
methanesulfonyl chloride

: 666752-57-4
2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Guidance literature:: C₁₄H₁₇ClN₄O₂S; tert-butyldimethylsilyl chloride; With 1H-imidazole; In DMF (N,N-dimethyl-formamide); for 24h;

methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield:

: 766-80-3
1-bromomethyl-3-chlorobenzene

: 666752-57-4
2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol; water / 2 h

2.1: acetic acid; sodium nitrite / water / 0.17 h

3.1: acetic acid; zinc / ethanol / 0.08 h / Heating / reflux

4.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h

4.2: 1 h

With 1H-imidazole; sodium hydroxide; acetic acid; zinc; sodium nitrite; In DMF (N,N-dimethyl-formamide); ethanol; water;

Reference yield:

: 666752-53-0
2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-4-pyrimidinol

: 666752-57-4
2-[(3-chlorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-5-[(methylsulfon-yl)amino]-4-pyrimidinyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; sodium nitrite / water / 0.17 h

2.1: acetic acid; zinc / ethanol / 0.08 h / Heating / reflux

3.1: 1H-imidazole / DMF (N,N-dimethyl-formamide) / 24 h

3.2: 1 h

With 1H-imidazole; acetic acid; zinc; sodium nitrite; In DMF (N,N-dimethyl-formamide); ethanol; water;