(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

Base Information

Chemical Name:(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid
CAS No.:1239579-37-3
Molecular Formula:C₅₈H₈₀O₁₄Si
Molecular Weight:1029.35
Hs Code.:

(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

Synonyms:(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

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Chemical Property of (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

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Technology Process of (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

There total 1 articles about (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1239579-41-9
(2S,4S,6S)-2-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-3,3-dimethyltetrahydro-2H-pyran-4-yl acetate

: 1239579-37-3
(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

Guidance literature:: With water; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 0 - 20 ℃; for 9h; Inert atmosphere;
DOI:10.1002/anie.201001200

Reference yield: 79.0%

: 1239579-37-3
(R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid

: 1239579-42-0
(1S,3R,7R,11S,15S,17R,21R,23S,25S,E)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-10,10,26,26-tetramethyl-5,12,19-trioxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-25-yl acetate

Guidance literature:: (R)-4-((2S,4S,6S)-4-acetoxy-6-(((2R,6R)-6-((E)-3-((2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-3-oxotetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-oxotetrahydro-2H-pyran-2-yl)methyl)-5,5-dimethyltetrahydro-2H-pyran-2-yl)-3-(tert-butyldiphenylsilyloxy)butanoic acid; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

With dmap; In tetrahydrofuran; toluene; at 45 ℃; for 14h; Inert atmosphere;
DOI:10.1002/anie.201001200