C₁₅H₁₂N₂O₃

Base Information

• Chemical Name: C₁₅H₁₂N₂O₃
• CAS No.: 1059628-84-0
• Molecular Formula: C₁₅H₁₂N₂O₃
• Molecular Weight: 268.272
• Mol file: 1059628-84-0.mol

Synonyms:C₁₅H₁₂N₂O₃

Chemical Property of C₁₅H₁₂N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₂N₂O₃

There total 4 articles about C₁₅H₁₂N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 3-(5-nitro-1H-indol-2-yl)benzoate (1059628-83-9) → C15H12N2O3 (1059628-84-0)

Guidance literature:

methyl 3-(5-nitro-1H-indol-2-yl)benzoate; With lithium borohydride; In tetrahydrofuran; for 24h;

With ammonium chloride; In tetrahydrofuran; water; Saturated solution;

DOI:10.1080/00397910903457415

Reference yield:

methyl 3-iodo-benzoate (618-91-7) → C15H12N2O3 (1059628-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: [Rh(coe)2Cl]2; cesium pivalate; tris(para-trifluoromethyl)phenyl phosphine / 1,4-dioxane / 72 h / Inert atmosphere; Reflux

2.1: sodium nitrate; sulfuric acid / 2 h / -20 °C

3.1: lithium borohydride / tetrahydrofuran / 24 h

3.2: Saturated solution

With sodium nitrate; lithium borohydride; [Rh(coe)2Cl]2; sulfuric acid; cesium pivalate; tris(para-trifluoromethyl)phenyl phosphine; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1080/00397910903457415

Reference yield:

methyl 3-(1H-indol-2-yl)benzoate (1059628-81-7) → C15H12N2O3 (1059628-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrate; sulfuric acid / 2 h / -20 °C

2.1: lithium borohydride / tetrahydrofuran / 24 h

2.2: Saturated solution

With sodium nitrate; lithium borohydride; sulfuric acid; In tetrahydrofuran;

DOI:10.1080/00397910903457415

upstream raw materials:

methyl 3-(5-nitro-1H-indol-2-yl)benzoate

methyl 3-(1H-indol-2-yl)benzoate

methyl 3-iodo-benzoate

3-Iodobenzoic acid

Downstream raw materials:

2-(3-bromomethyl-phenyl)-5-nitro-1H-indole