Technology Process of 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl)heptanoate guanidinium
There total 2 articles about 7-((2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl)heptanoate guanidinium which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methyllithium / formaldehyde diethyl acetal; tetrahydrofuran / -70 - -60 °C / Inert atmosphere
1.2: 0.5 h / -50 - -40 °C / Inert atmosphere
1.3: -60 - -50 °C / Inert atmosphere
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 60 °C / 3000.3 Torr
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -70 - -60 °C
3.2: -70 - 0 °C
4.1: trifluoroacetic acid / acetonitrile / 16 h / 15 - 30 °C
5.1: Lipase PS SD / acetone / 22 h / 50 - 60 °C / pH 8 / Enzymatic reaction
6.1: sodium methylate / methanol / 1 h / 25 °C
6.2: 1 h / 25 °C
With
oxalyl dichloride; methyllithium; hydrogen; sodium methylate; dimethyl sulfoxide; trifluoroacetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; formaldehyde diethyl acetal; dichloromethane; water; ethyl acetate; acetone; acetonitrile;
- Guidance literature:
-
guanidine hydrochloride;
With
sodium methylate;
In
methanol;
at 25 ℃;
for 1h;
lubiprostone;
In
methanol;
at 25 ℃;
for 1h;
![(Z)-7-[(3R)-3-(tert-butyldimethylsilanyloxy)-5-oxo-cyclopent-1-enyl]hept-5-enoic acid isopropyl ester](/Databaselist/images/loading.webp)
