(1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

Base Information

Chemical Name:(1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol
CAS No.:952651-86-4
Molecular Formula:C₃₂H₃₆O₃Si
Molecular Weight:496.722
Hs Code.:

Synonyms:(1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

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Chemical Property of (1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

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Technology Process of (1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

There total 9 articles about (1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952651-74-0
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propionaldehyde

: phenylmagnesium bromide

: 952651-86-4
(1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

: (1'R,1S)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

Guidance literature:: With magnesium bromide; In diethyl ether; dichloromethane; at -78 ℃; for 0.333333h;
DOI:10.1021/ol071382h

Reference yield:

: 952652-05-0
(-)-(R)-(1-methoxy-2,2,2-triphenylethyl)dimethylsilane

: 952651-86-4
(1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Br₂ / CH₂Cl₂ / -78 °C

1.2: 96 percent / triethylamine; DMAP / CH₂Cl₂ / 1 h / 0 - 23 °C

2.1: 96 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

3.1: MgBr₂ / CH₂Cl₂; diethyl ether / 0.33 h / -78 °C

With oxalyl dichloride; bromine; dimethyl sulfoxide; triethylamine; magnesium bromide; In diethyl ether; dichloromethane; 2.1: Swern oxidation;
DOI:10.1021/ol071382h

Reference yield:

: 952652-08-3
(1'R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]propan-1-ol

: 952651-86-4
(1'R,1R)-3-[(1-methoxy-2,2,2-triphenylethyl)dimethylsilyloxy]-1-phenylpropanol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / (COCl)2; DMSO; triethylamine / CH₂Cl₂ / -78 - 23 °C

2: MgBr₂ / CH₂Cl₂; diethyl ether / 0.33 h / -78 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; magnesium bromide; In diethyl ether; dichloromethane; 1: Swern oxidation;
DOI:10.1021/ol071382h