{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

Base Information

Chemical Name:{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester
CAS No.:1034592-78-3
Molecular Formula:C₃₁H₂₈Cl₂FN₃O₃
Molecular Weight:580.486
Hs Code.:

Synonyms:{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

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Chemical Property of {1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

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Technology Process of {1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

There total 1 articles about {1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691875-81-7
4-(2-fluoro-phenyl)piperidine hydrochloride

: 1034265-89-8
1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-ethoxycarbonylmethyl-1H-pyrazole-3-carboxylic acid

: 1034592-78-3
{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

Guidance literature:: 1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-ethoxycarbonylmethyl-1H-pyrazole-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 3h;

4-(2-fluoro-phenyl)piperidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

Reference yield:

: 1034592-78-3
{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

: 1160756-33-1
[1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-4-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-[4-(2-fluoro-phenyl)-piperidin-1-yl]-methanone

Guidance literature:: {1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester; With sodium tetrahydroborate; In ethanol; at 20 ℃; for 48h;

With water; ammonium chloride; In ethanol;

Reference yield:

: 1034592-78-3
{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester

: 1034591-86-0
{1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: {1-(2-chloro-phenyl)-5-(4-chloro-phenyl)-3-[4-(2-fluoro-phenyl)-piperidine-1-carbonyl]-1H-pyrazol-4-yl}-acetic acid ethyl ester; With lithium hydroxide; water; In tetrahydrofuran;

With hydrogenchloride; water;