(4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

Base Information

Chemical Name:(4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone
CAS No.:1362909-87-2
Molecular Formula:C₁₉H₁₄FN₅O
Molecular Weight:347.351
Hs Code.:

Synonyms:(4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

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Chemical Property of (4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

Chemical Property:

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Technology Process of (4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

There total 3 articles about (4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3034-41-1
1-methyl-4-nitro-1H-imidazole

: 1241914-72-6
(4-chloroquinazoline-2-yl)(4-fluorophenyl)methanone

: 1362909-87-2
(4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

Guidance literature:: 1-methyl-4-nitro-1H-imidazole; With hydrogen; palladium 10% on activated carbon; In ethanol; for 0.5h;

(4-chloroquinazoline-2-yl)(4-fluorophenyl)methanone; With triethylamine; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 1362909-87-2
(4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / -40 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h

2.2: 20 °C

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;

Reference yield:

: 34632-69-4
ethyl 4-chloro-quinazoline-2-carboxylate

: 1362909-87-2
(4-fluorophenyl)(4-(1-methyl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 4 h / -40 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 0.5 h

2.2: 20 °C

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;