2(1H)-NAPHTHALENONE,OCTAHYDRO

Base Information

• Chemical Name: 2(1H)-NAPHTHALENONE,OCTAHYDRO
• CAS No.: 1197-95-1
• Molecular Formula: C₁₁H₁₈O
• Molecular Weight: 166.263
• Hs Code.: 2914299000
• Mol file: 1197-95-1.mol

Synonyms:2(1H)-Naphthalenone,3,4,4aa,5,6,7,8,8a-octahydro-8ab-methyl- (7CI);2(1H)-Naphthalenone, octahydro-8a-methyl-, trans- (8CI); 9b-Methyl-2-decalone

Chemical Property of 2(1H)-NAPHTHALENONE,OCTAHYDRO

Chemical Property:

• PSA: 17.07000
• LogP: 2.93590

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-NAPHTHALENONE,OCTAHYDRO

There total 15 articles about 2(1H)-NAPHTHALENONE,OCTAHYDRO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4aS)-4a-methyl-trans-4a,5,8,8a-tetrahydro-1H-naphthalen-2-one (17429-21-9) → (+)-trans-9-Methyl-decalon-2 (1197-95-1,2530-17-8,3213-60-3,5872-43-5,5872-45-7,6109-48-4,6109-49-5,6109-51-9,91253-93-9)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂ / Pd-CaCO₃

2: N₂H₄, KOH / bis-(2-hydroxy-ethyl) ether

3: NBS, aq. HClO₄

4: CrO₃, aq. H₂SO₄ / acetone

5: Zn, AcOH

With chromium(VI) oxide; potassium hydroxide; N-Bromosuccinimide; perchloric acid; sulfuric acid; hydrogen; acetic acid; hydrazine; zinc; Lindlar's catalyst; In acetone; diethylene glycol;

DOI:10.1021/ja01063a020

Reference yield:

(4aS)-4a-methyl-trans-3,4,4a,5,8,8a-hexahydro-1H-naphthalen-2-one (22489-63-0,55283-48-2,80800-82-4,91967-81-6) → (+)-trans-9-Methyl-decalon-2 (1197-95-1,2530-17-8,3213-60-3,5872-43-5,5872-45-7,6109-48-4,6109-49-5,6109-51-9,91253-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: N₂H₄, KOH / bis-(2-hydroxy-ethyl) ether

2: NBS, aq. HClO₄

3: CrO₃, aq. H₂SO₄ / acetone

4: Zn, AcOH

With chromium(VI) oxide; potassium hydroxide; N-Bromosuccinimide; perchloric acid; sulfuric acid; acetic acid; hydrazine; zinc; In acetone; diethylene glycol;

DOI:10.1021/ja01063a020

Reference yield:

trans-9-Methyl-Δ2-octahydro-naphthalin (62859-37-4) → (+)-trans-9-Methyl-decalon-2 (1197-95-1,2530-17-8,3213-60-3,5872-43-5,5872-45-7,6109-48-4,6109-49-5,6109-51-9,91253-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS, aq. HClO₄

2: CrO₃, aq. H₂SO₄ / acetone

3: Zn, AcOH

With chromium(VI) oxide; N-Bromosuccinimide; perchloric acid; sulfuric acid; acetic acid; zinc; In acetone;

DOI:10.1021/ja01063a020

upstream raw materials:

(4aS)-4a-methyl-trans-3,4,4a,5,8,8a-hexahydro-1H-naphthalen-2-one

trans-9-Methyl-Δ²-octahydro-naphthalin

(4aS)-4a-methyl-trans-4a,5,8,8a-tetrahydro-1H-naphthalen-2-one

methyl magnesium iodide

Downstream raw materials:

1β-methylcyclohexane-1α,2β-diacetic acid

cis-9-Methyl-3-octalin-2-on

(+/-)-(1-methyl-cyclohexane-1r,2c-diyl)-di-acetic acid

9-methyl-cis-decaline