(2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Base Information

• Chemical Name: (2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine
• CAS No.: 894433-05-7
• Molecular Formula: C₂₉H₂₈N₂O₅S
• Molecular Weight: 516.618
• Mol file: 894433-05-7.mol

Synonyms:(2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Chemical Property of (2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

There total 1 articles about (2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

nitromethane (75-52-5) + (2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid (639457-00-4) → (2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (894433-05-7)

Guidance literature:

(2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 1h;

nitromethane; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 17h;

DOI:10.1002/ardp.200500139

Reference yield: 86.0%

(2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (894433-05-7) + N-methoxylamine hydrochloride (593-56-6) → (2S,4S)-2-(1-methoxyimino-2-nitroethyl)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (894433-08-0)

Guidance literature:

In pyridine; at 50 ℃; for 16h;

DOI:10.1002/ardp.200500139

Reference yield: 83.0%

(2S,4S)-2-[(1-oxo-2-nitro)ethyl]-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (894433-05-7) → (2S,4S)-2-(1-Hydroxy-2-nitro-ethyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester (894433-06-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1002/ardp.200500139

upstream raw materials:

nitromethane

(2S,4S)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine-2-carboxylic acid

Downstream raw materials:

(2S,4S)-2-(1-Hydroxy-2-nitro-ethyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

(2S,4S)-2-{1-[(E)-Hydroxyimino]-2-nitro-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

(2S,4S)-2-(1-methoxyimino-2-nitroethyl)-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine

(C₆H₅)3CSC₄H₆NCO₂CH₂CHCH₂CNOCH₃CH₂NHSO₂NHCH₂CH₃