4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Base Information

Chemical Name:4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
CAS No.:747398-72-7
Molecular Formula:C₂₅H₃₅N₃O₂
Molecular Weight:409.572
Hs Code.:

Synonyms:4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

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Chemical Property of 4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Chemical Property:

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Technology Process of 4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

There total 4 articles about 4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58287-77-7
N,N-diethyl-4-formylbenzamide

: 747398-72-7
4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / Heating

2: tetrahydrofuran / 3 h / 20 °C

3: H₂; aq. AcOH / 10percent Pd/C / Heating

With hydrogen; acetic acid; 10percent Pd/C; In tetrahydrofuran; benzene; 1: Condensation / 2: Substitution / 3: Hydrogenolysis;
DOI:10.1021/jm0001222

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 747398-72-7
4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: EDCI / CH₂Cl₂

2: benzene / Heating

3: tetrahydrofuran / 3 h / 20 °C

4: H₂; aq. AcOH / 10percent Pd/C / Heating

With hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In tetrahydrofuran; dichloromethane; benzene; 1: Condensation / 2: Condensation / 3: Substitution / 4: Hydrogenolysis;
DOI:10.1021/jm0001222

Reference yield:

: 4-[(4-allyl-2,5-dimethyl-piperazin-1-yl)-benzotriazol-1-yl-methyl]-N,N-diethyl-benzamide

: 747398-72-7
4-[(αS)-α-((2R,5S)-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / 20 °C

2: H₂; aq. AcOH / 10percent Pd/C / Heating

With hydrogen; acetic acid; 10percent Pd/C; In tetrahydrofuran; 1: Substitution / 2: Hydrogenolysis;
DOI:10.1021/jm0001222