(S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione

Base Information

• Chemical Name: (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione
• CAS No.: 1280555-51-2
• Molecular Formula: C₃₁H₃₃FN₆O₆S
• Molecular Weight: 636.704
• Mol file: 1280555-51-2.mol

Synonyms:(S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione

Chemical Property of (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione

There total 1 articles about (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

NSC 373854 (107089-77-0) + (S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine (198410-25-2) → (S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione (1280555-51-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2010.12.028

Reference yield: 89.0%

(S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione (1280555-51-2) → C23H27FN6O4S (1280555-57-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2010.12.028

Reference yield:

(S)-[{N-3-[3-fluoro-4-(4-carbobenzoxypiperazino)phenyl]-2-oxo-5-oxazolidinyl}methyl]amino-4-ethyl-1,4-dihydro-1,2,4-benzothiadiazine 1,1-dione (1280555-51-2) → C36H34ClFN6O6S (1280555-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2010.12.028

upstream raw materials:

NSC 373854

(S)-N-(3-(3-fluoro-4-((N-4-carbobenzoxy)piperazin-1-yl)phenyl)-2-oxo-oxazolidin-5-yl)methylamine

Downstream raw materials:

C₂₃H₂₇FN₆O₄S

C₃₆H₃₄ClFN₆O₆S