(2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Base Information

Chemical Name:(2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal
CAS No.:475051-47-9
Molecular Formula:C₂₉H₄₆O₃Si₂
Molecular Weight:498.853
Hs Code.:

Synonyms:(2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Suppliers and Price of (2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

There total 16 articles about (2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 475051-58-2
(2S,3S,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanol

: 475051-47-9
(2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane;
DOI:10.1021/jo8021583

Reference yield:

: 374896-36-3
ethyl (2R,3S,4S)-2-bromo-5-(tert-butyldimethylsiloxy)-3-hydroxy-2,4-dimethylpentanoate

: 475051-47-9
(2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / Mg; ethelene dibromide; Bu₃SnH / Et₃B / CH₂Cl₂; diethyl ether / 2 h / 0 °C

2: 87 percent / 2,6-lutidine / 1 h / 20 °C

3: 80 percent / DIBALH / CH₂Cl₂ / 3 h / -78 °C

4: 92 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

5: 90 percent / pyridinium p-toluenesulfonate / methanol / 20 h / 20 °C

6: 87 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; oxalyl dichloride; tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; magnesium; dimethyl sulfoxide; ethylene dibromide; triethylamine; triethyl borane; In methanol; diethyl ether; dichloromethane; 6: Swern oxidation;
DOI:10.1021/jo034901c

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 475051-47-9
(2R,3R,4S)-3-(tert-butyldimethylsiloxy)-5-(tert-butyldiphenylsiloxy)-2,4-dimethylpentanal

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / 2,6-lutidine / 1 h / 20 °C

2: 80 percent / DIBALH / CH₂Cl₂ / 3 h / -78 °C

3: 92 percent / imidazole / CH₂Cl₂ / 1 h / 20 °C

4: 90 percent / pyridinium p-toluenesulfonate / methanol / 20 h / 20 °C

5: 87 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; oxalyl dichloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; 5: Swern oxidation;
DOI:10.1021/jo034901c