Diethyl 3-(ethoxycarbonyl)hexanediate

Base Information

• Chemical Name: Diethyl 3-(ethoxycarbonyl)hexanediate
• CAS No.: 1188-35-8
• Molecular Formula: C13H22 O6
• Molecular Weight: 274.314
• Hs Code.: 2917190090
• Mol file: 1188-35-8.mol

Synonyms:1,2,4-Butanetricarboxylicacid, triethyl ester (6CI,7CI,8CI,9CI); 3-Ethoxycarbonylhexanedioic aciddiethyl ester; Triethyl (?à)-1,2,4-butanetricarboxylate

Chemical Property of Diethyl 3-(ethoxycarbonyl)hexanediate

Chemical Property:

• PSA: 78.90000
• LogP: 1.46220

Purity/Quality:

98%,99%, ^*data from raw suppliers

TriethylButane-1,2,4-tricarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Diethyl 3-(ethoxycarbonyl)hexanediate

There total 16 articles about Diethyl 3-(ethoxycarbonyl)hexanediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + butane-1,2,4-tricarboxylic acid (923-42-2) → 3-ethoxycarbonylhexane-1,6-dioic acid diethyl ester (1188-35-8)

Guidance literature:

With sulfuric acid; for 24h; Heating / reflux;

Reference yield: 85.0%

butane-1,2,2,4-tetracarboxylic acid tetraethyl ester (70600-48-5) → 3-ethoxycarbonylhexane-1,6-dioic acid diethyl ester (1188-35-8)

Guidance literature:

With water; sodium chloride; In dimethyl sulfoxide; at 185 - 190 ℃; for 5.5h;

DOI:10.1007/BF00961357

Reference yield:

ethanol (64-17-5) + butane-1,2,4-tricarbonitrile (5238-65-3) → 3-ethoxycarbonylhexane-1,6-dioic acid diethyl ester (1188-35-8)

Guidance literature:

With sulfuric acid; at 135 ℃;

upstream raw materials:

ethanol

butane-1,2,4-tricarbonitrile

butane-1,2,4-tricarboxylic acid

4-cyano-butane-1,2,2-tricarboxylic acid triethyl ester

Downstream raw materials:

2-methyl-3-oxo-cyclopentanecarboxylic acid

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE". Page/Page column 24; 25. . Retrieved 2016/05/02.
• 2、 Sizov, A. Yu.,Dombrovskii, V. A.,Yanovskaya, L. A.. "SYNTHESIS OF POLYFUNCTIONAL ALIPHATIC CARBONYL COMPOUNDS UNDER PHASE-TRANSFER CONDITIONS". . p. 955 - 961. Retrieved 2007/10/02.