2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

Base Information

Chemical Name:2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester
CAS No.:1350551-63-1
Molecular Formula:C₁₉H₁₈FN₃O₃S
Molecular Weight:387.435
Hs Code.:

Synonyms:2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

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Chemical Property of 2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

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Technology Process of 2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

There total 8 articles about 2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350551-62-0
2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide

: 420-37-1
trimethoxonium tetrafluoroborate

: 1350551-63-1
2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

Guidance literature:: In acetonitrile; at 20 ℃; for 0.833333h; Cooling;

Reference yield:

: 1350551-58-4
tert-butyl(2-fluoro-5-methoxyphenoxy)dimethylsilane

: 1350551-63-1
2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / 3 h / -72 - -56 °C / Inert atmosphere

1.3: 10 - 20 °C

2.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

2.2: 22 h / 40 °C

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

4.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

5.1: acetonitrile / 0.83 h / 20 °C / Cooling

With diammonium sulfide; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; water; guanidine hydrochloride; potassium carbonate; sodium iodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 459-60-9
1-fluoro-4-methoxybenzene

: 1350551-63-1
2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / -70 °C / Inert atmosphere

1.2: 1 h

1.3: -10 - 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

3.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / 3 h / -72 - -56 °C / Inert atmosphere

3.3: 10 - 20 °C

4.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

4.2: 22 h / 40 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

6.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

7.1: acetonitrile / 0.83 h / 20 °C / Cooling

With diammonium sulfide; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; water; guanidine hydrochloride; potassium carbonate; triethylamine; sodium iodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;