2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide

Base Information

• Chemical Name: 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide
• CAS No.: 1350551-62-0
• Molecular Formula: C₁₈H₁₈FN₃O₃S
• Molecular Weight: 375.424
• Mol file: 1350551-62-0.mol

Synonyms:2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide

Chemical Property of 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide

There total 7 articles about 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-({cyano[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]methyl}amino)benzonitrile (1350551-61-9) → 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide (1350551-62-0)

Guidance literature:

With diammonium sulfide; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

trimethylsilyl cyanide (7677-24-9) + 2-fluoro-3-(2-hydroxyethoxy)-5-methoxybenzaldehyde (1362252-60-5) + 4-Aminobenzonitrile (873-74-5) → 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide (1350551-62-0)

Guidance literature:

trimethylsilyl cyanide; 2-fluoro-3-(2-hydroxyethoxy)-5-methoxybenzaldehyde; 4-Aminobenzonitrile; With methanol; guanidine hydrochloride; at 40 ℃; for 19h; Inert atmosphere;

With diammonium sulfide; water; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

tert-butyl(2-fluoro-5-methoxyphenoxy)dimethylsilane (1350551-58-4) → 2-(4-cyanophenylamino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetamide (1350551-62-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / 3 h / -72 - -56 °C / Inert atmosphere

1.3: 10 - 20 °C

2.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

2.2: 22 h / 40 °C

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

4.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

With diammonium sulfide; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; water; guanidine hydrochloride; potassium carbonate; sodium iodide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;

upstream raw materials:

trimethylsilyl cyanide

2-fluoro-3-(2-hydroxyethoxy)-5-methoxybenzaldehyde

4-Aminobenzonitrile

1-fluoro-4-methoxybenzene

Downstream raw materials:

2-(4-cyanophenylimino)-2-[2-fluoro-3-(2-hydroxyethoxy)-5-methoxyphenyl]thioacetimidate methyl ester

carbonic acid 2-{3-[(4-cyanophenylamino)-(5-oxo-1-pyrimidin-2-yl-4,5-dihydro-1H-[1,2,4]-triazol-3-yl)methyl]-2-fluoro-5-methoxyphenoxy}ethyl ester methyl ester

3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester methanesulfonate

3-methoxy-2,2-dimethylpropionic acid 5-[(R)-[3-(2-acetoxyethoxy)-2-fluoro-5-methoxyphenyl]-(4-{amino[2-methylallyloxycarbonylimino]methyl}phenylamino)methyl]-2-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yloxymethyl ester hydrochloride