4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

Base Information

Chemical Name:4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine
CAS No.:1547229-02-6
Molecular Formula:C₁₄H₁₁F₃N₂O
Molecular Weight:280.249
Hs Code.:

Synonyms:4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

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Chemical Property of 4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

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Technology Process of 4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

There total 4 articles about 4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1474024-67-3
(R)-4-(1-(2-(2,4-difluorophenyl)oxirane-2-yl)vinyl)-5-fluoropyrimidine

: 1474024-68-4
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

: 1547229-02-6
4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

Guidance literature:: With trisylhydrazine; sodium hydrogencarbonate; In methanol; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo4019528

Reference yield:

: 1474024-65-1
(R)-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)methanol

: 1474024-68-4
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

: 1547229-02-6
4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide; dodecyl methyl sulfide / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere

1.2: 2 h / -30 °C / Inert atmosphere

2.1: potassium tert-butylate / toluene / 1 h / 120 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

2.3: 1 h / 65 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; trisylhydrazine / methanol / 18 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; dodecyl methyl sulfide; trisylhydrazine; potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; methanol; toluene; 1.1: |Corey-Kim Oxidation / 1.2: |Corey-Kim Oxidation / 2.1: |Wittig Olefination / 2.2: |Wittig Olefination;
DOI:10.1021/jo4019528

Reference yield:

: 1474024-66-2
(R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)-methanone

: 1474024-68-4
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

: 1547229-02-6
4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / toluene / 1 h / 120 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

1.3: 1 h / 65 °C / Inert atmosphere

2.1: sodium hydrogencarbonate; trisylhydrazine / methanol / 18 h / 20 °C / Inert atmosphere

With trisylhydrazine; potassium tert-butylate; sodium hydrogencarbonate; In methanol; toluene; 1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1021/jo4019528