4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

Base Information

Chemical Name:4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine
CAS No.:1474024-68-4
Molecular Formula:C₁₄H₁₁F₃N₂O
Molecular Weight:280.249
Hs Code.:

Synonyms:4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

Suppliers and Price of 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

Chemical Property:

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Technology Process of 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

There total 8 articles about 4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1474024-67-3
(R)-4-(1-(2-(2,4-difluorophenyl)oxirane-2-yl)vinyl)-5-fluoropyrimidine

: 1474024-68-4
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

Guidance literature:: With trisylhydrazine; sodium hydrogencarbonate; In methanol; at 20 ℃; for 18h;

Reference yield: 57.0%

: 1474024-67-3
(R)-4-(1-(2-(2,4-difluorophenyl)oxirane-2-yl)vinyl)-5-fluoropyrimidine

: 1474024-68-4
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

: 1547229-02-6
4-((R)-1-((R)-2-(2,4-difluorophenyl)oxiran-2-yl)ethyl)-5-fluoropyrimidine

Guidance literature:: With trisylhydrazine; sodium hydrogencarbonate; In methanol; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jo4019528

Reference yield:

: 1474024-66-2
(R)-(2-(2,4-difluorophenyl)oxiran-2-yl)(5-fluoropyrimidin-4-yl)-methanone

: 1474024-68-4
4-((S)-1-((R)-2-(2,4-difluorophenyl)oxirane-2-yl)ethyl)-5-fluoropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / toluene / 1 h / 120 °C / Inert atmosphere

1.2: 3 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: trisylhydrazine; sodium hydrogencarbonate / methanol / 18 h / 20 °C

With trisylhydrazine; potassium tert-butylate; sodium hydrogencarbonate; In methanol; toluene;