4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

Base Information

Chemical Name:4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide
CAS No.:1271520-91-2
Molecular Formula:C₁₉H₂₆N₄O₆S
Molecular Weight:438.505
Hs Code.:

Synonyms:4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

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Chemical Property of 4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

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Technology Process of 4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

There total 11 articles about 4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1271521-36-8
N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

: 1271520-91-2
4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 192h;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1271520-91-2
4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / butanone / 23 h / 20 °C / Reflux

2.1: sodium hydroxide; water / tetrahydrofuran / 23 h / 45 °C / Reflux

2.2: pH 6

3.1: N-cyclohexyl-cyclohexanamine / dichloromethane / 0.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 3 h / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 48 h / 20 °C

6.2: pH 6

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h

7.2: 20 h / 20 °C

8.1: trifluoroacetic acid / 192 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-cyclohexyl-cyclohexanamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;

Reference yield:

: 554450-77-0
dimethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)malonate

: 1271520-91-2
4-but-2-ynyloxy-N-[2-hydroxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 2 - 20 °C

1.2: 20 h / 2 - 20 °C

2.1: hydrazine hydrate / methanol / 3 h / -5 - 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 48 h / 20 °C

5.2: pH 6

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h

6.2: 20 h / 20 °C

7.1: trifluoroacetic acid / 192 h / 20 °C

With hydrazine hydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;