N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

Base Information

Chemical Name:N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide
CAS No.:1271521-36-8
Molecular Formula:C₂₃H₃₄N₄O₆S
Molecular Weight:494.612
Hs Code.:

Synonyms:N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

Suppliers and Price of N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

There total 10 articles about N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1271521-35-7
3-(4-but-2-ynyloxybenzoylamino)-2-(4-methane-sulphonylpiperazin-1-yl)propanoic acid

: 39684-28-1
O-(tert-butyl)hydroxylamine hydrochloride

: 1271521-36-8
N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

Guidance literature:: 3-(4-but-2-ynyloxybenzoylamino)-2-(4-methane-sulphonylpiperazin-1-yl)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; for 0.333333h;

O-(tert-butyl)hydroxylamine hydrochloride; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1271521-36-8
N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / butanone / 23 h / 20 °C / Reflux

2.1: sodium hydroxide; water / tetrahydrofuran / 23 h / 45 °C / Reflux

2.2: pH 6

3.1: N-cyclohexyl-cyclohexanamine / dichloromethane / 0.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 3 h / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 48 h / 20 °C

6.2: pH 6

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h

7.2: 20 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-cyclohexyl-cyclohexanamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;

Reference yield:

: 554450-77-0
dimethyl 2-(4-tert-butoxycarbonylpiperazin-1-yl)malonate

: 1271521-36-8
N-[2-tert-butoxycarbamoyl-2-(4-methanesulphonylpiperazin-1-yl)ethyl]-4-but-2-ynyloxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 2 - 20 °C

1.2: 20 h / 2 - 20 °C

2.1: hydrazine hydrate / methanol / 3 h / -5 - 20 °C

3.1: triethylamine / tetrahydrofuran / 1 h / 20 °C

4.1: triethylamine / dichloromethane / 3 h / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 48 h / 20 °C

5.2: pH 6

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.33 h

6.2: 20 h / 20 °C

With hydrazine hydrate; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;