C₂₁H₂₈F₃NO₂

Base Information

Chemical Name:C₂₁H₂₈F₃NO₂
CAS No.:1422558-61-9
Molecular Formula:C₂₁H₂₈F₃NO₂
Molecular Weight:383.454
Hs Code.:

C<sub>21</sub>H<sub>28</sub>F<sub>3</sub>NO<sub>2</sub>

Synonyms:C₂₁H₂₈F₃NO₂

Suppliers and Price of C₂₁H₂₈F₃NO₂

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of C₂₁H₂₈F₃NO₂

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₂₁H₂₈F₃NO₂

There total 4 articles about C₂₁H₂₈F₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.3%

: 402-43-7
p-trifluoromethylphenyl bromide

: 1422558-39-1
C₂₀H₃₆BNO₄

: 1422558-61-9
C₂₁H₂₈F₃NO₂

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl; sodium t-butanolate; In water; toluene; at 80 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ja3104582

Reference yield:

: 236406-37-4
tert-butyl 4-(hydroxymethyl)-4-(prop-2-en-1-yl)piperidine-1-carboxylate

: 1422558-61-9
C₂₁H₂₈F₃NO₂

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C

2: copper(l) chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium tert-butylate / tetrahydrofuran / 4 h / 30 °C / Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl; sodium t-butanolate / water; toluene / 48 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbon tetrabromide; dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl; potassium tert-butylate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; water; toluene; 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/ja3104582

Reference yield:

: 1422558-88-0
tert-butyl 4-allyl-4-(bromomethyl)piperidine-1-carboxylate

: 1422558-61-9
C₂₁H₂₈F₃NO₂

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) chloride; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; potassium tert-butylate / tetrahydrofuran / 4 h / 30 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl; sodium t-butanolate / water; toluene / 48 h / 80 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl; potassium tert-butylate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; water; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/ja3104582