N,N'-DIBENZYLGLYCINAMIDE

Base Information

• Chemical Name: N,N'-DIBENZYLGLYCINAMIDE
• CAS No.: 1089-31-2
• Molecular Formula: C16H18 N2 O
• Molecular Weight: 254.332
• Hs Code.: 2924299090
• Mol file: 1089-31-2.mol

Synonyms:Acetamide,N-benzyl-2-(benzylamino)- (7CI,8CI); N,N'-Dibenzylglycinamide;N-Benzyl-2-(benzylamino)acetamide

Chemical Property of N,N'-DIBENZYLGLYCINAMIDE

Chemical Property:

• Boiling Point: 465.2°Cat760mmHg
• Flash Point: 178.1°C
• PSA: 41.13000
• Density: 1.102g/cm³
• LogP: 2.87440

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N’-Dibenzylglycinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Levocetirizine (C281106).

Technology Process of N,N'-DIBENZYLGLYCINAMIDE

There total 11 articles about N,N'-DIBENZYLGLYCINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 2-(benzylamino)acetate (6436-90-4) + benzylamine (100-46-9) → N-(2-(benzylamino)-2-oxoethyl)benzamide (1089-31-2)

Guidance literature:

With lanthanum(lll) triflate; In toluene; at 20 ℃; for 12h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol500593v

Reference yield: 94.0%

2-Bromoacetyl bromide (598-21-0) + benzylamine (100-46-9) → N-(2-(benzylamino)-2-oxoethyl)benzamide (1089-31-2)

Guidance literature:

In acetonitrile; at 0 - 20 ℃; for 12h;

DOI:10.1002/ejoc.201300427

Reference yield: 93.0%

benzylamine (100-46-9) + N-Benzylethanolamine (104-63-2) → N-(2-(benzylamino)-2-oxoethyl)benzamide (1089-31-2)

Guidance literature:

With [RuCl₂(p-cymene)(iPr₂-imy)]; potassium tert-butylate; tricyclohexylphosphine; In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201000569

upstream raw materials:

phenyl chloroacetate

benzylamine

chloroacetic acid ethyl ester

water

Downstream raw materials:

2-acetoxy-N-benzyl-N-(2-benzylamino-2-oxoethyl)-3-(2-methoxyethyl)-3-butenamide

1,3-dibenzyl-4-imidazolidinone

Refernces

• 1、 Potopnyk, Mykhaylo A.,Jarosz, Slawomir. "Synthesis and complexation properties of unsymmetrical sucrose-based receptors". . p. 5117 - 5126. Retrieved 2013.
• 2、 Mitra, Aurpon W.,Hansen, Marvin M.,Laurila, Michael E.,Kolis, Stanley P.,Martinelli, Joseph R.. "α-Aminoamides as ligands in Goldberg amidations". supporting information. p. 6580 - 6583. Retrieved 2013/11/19.