Technology Process of 4-cyclohexyl-2-butynal
There total 1 articles about 4-cyclohexyl-2-butynal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
prop-2-ynylcyclohexane;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 0.25h;
Inert atmosphere;
Schlenk technique;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/ol503055x
- Guidance literature:
-
With
acetic anhydride; trifluoroacetic acid;
at 20 ℃;
for 0.25h;
Inert atmosphere;
DOI:10.1055/s-0036-1588802
- Guidance literature:
-
With
ethanol; chloro[(2’,4’,6’-triisopropyl-3,4,5,6-tetramethyl-1,1’-biphenyl-2-yl)di-tert-butylphosphine]gold(I); water; silver trifluoromethanesulfonate;
In
tetrahydrofuran;
at 75 ℃;
for 24h;
stereoselective reaction;
Inert atmosphere;
Glovebox;
Darkness;
DOI:10.1021/ol503055x
