Synonyms:carbamic acid, methyl ester;methyl carbamate
99% *data from raw suppliers
Methyl Carbamate *data from reagent suppliers
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There total 69 articles about Methyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 98.8%
Reference yield: 90.0%
The research presents a study on the preparation of methyl (2-hydroxynaphthalen-1-yl)(aryl)methyl/benzylcarbamate derivatives using magnesium (II) 2,2,2-trifluoroacetate as an efficient catalyst. The methodology involves multi-component condensation reactions of aldehydes, 2-naphthol, and methyl/benzyl carbamate, resulting in the synthesis of various derivatives in high yields. The catalyst, Mg(OOCCF3)2, was prepared from trifluoroacetic acid and magnesium chloride and characterized through powder X-ray diffraction. The experiments involved optimizing reaction conditions such as catalyst amount, temperature, and solvent, with the best results achieved under solvent-free conditions at 100°C using 0.1 mmol of catalyst. Various aromatic aldehydes were tested, and the reaction was influenced by the electronic and steric properties of the aldehydes. The products were purified by simple filtration and crystallization from ethanol, and their structures were confirmed using NMR and IR spectroscopy, as well as elemental analysis. The study demonstrates an efficient method for synthesizing 1-carbamatoalkyl 2-naphthol derivatives with advantages such as good yields, simple procedure, shorter reaction times, and milder conditions.
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