N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine

Base Information

• Chemical Name: N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine
• CAS No.: 1055262-04-8
• Molecular Formula: C₃₆H₄₂N₁₀O
• Molecular Weight: 630.796

Synonyms:N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine

Chemical Property of N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine

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Technology Process of N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine

There total 7 articles about N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4-(azidomethyl)-3-methyl-5-phenylisoxazole (1055263-52-9) + N1-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridine-6-yl)-2,2-dimethyl-N3-(pent-4-ynyl)propane-1,3-diamine (1055262-88-8) → N1-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N3-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine (1055262-04-8)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In methanol; water; at 20 ℃; for 24h;

Reference yield:

3,6-dichloro-4-cyclobutylpyridazine (107228-57-9) → N1-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N3-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine (1055262-04-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine hydrochloride / para-xylene / 24 h / 130 °C / Heating / reflux

2: 1,4-dioxane / 24 h / 80 °C / Neat (no solvent)

3: copper(II) sulfate; sodium L-ascorbate / methanol; water / 24 h / 20 °C

With triethylamine hydrochloride; copper(II) sulfate; sodium L-ascorbate; In 1,4-dioxane; methanol; para-xylene; water;

Reference yield:

1-bromo-4-pentyne (28077-72-7) → N1-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N3-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine (1055262-04-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane

2: 1,4-dioxane / 24 h / 80 °C / Neat (no solvent)

3: copper(II) sulfate; sodium L-ascorbate / methanol; water / 24 h / 20 °C

With copper(II) sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; In 1,4-dioxane; methanol; water;

upstream raw materials:

4-(azidomethyl)-3-methyl-5-phenylisoxazole

N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridine-6-yl)-2,2-dimethyl-N₃-(pent-4-ynyl)propane-1,3-diamine

3,6-dichloro-4-cyclobutylpyridazine

1-bromo-4-pentyne

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