28077-72-7

Basic information

• Product Name: 1-BROMO-4-PENTYNE
• Synonyms: 4-PENTYNYL BROMIDE;1-BROMO-4-PENTYNE;5-Bromo-1-pentyne;5-Bromopentyne;5-broMopent-1-yne;1-Pentyne, 5-broMo-
• CAS NO: 28077-72-7
• Molecular Formula: C₅H₇Br
• Molecular Weight: 147.01
• Product Categories: Aliphatics
• Mol File: 28077-72-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 134 °C(Press: 763 Torr)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• Solubility: Acetone, Dichloromethane
• CAS DataBase Reference: 1-BROMO-4-PENTYNE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-PENTYNE(28077-72-7)
• EPA Substance Registry System: 1-BROMO-4-PENTYNE(28077-72-7)

Safety Data

• Hazardous Substances Data: 28077-72-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

5-Bromo-1-pentyne (cas# 28077-72-7) is a useful reagent for the synthesis of spirocyclic compounds.

InChI:InChI=1S/C5H7Br/c1-2-3-4-5-6/h1H,3-5H2

Upstream product

• 1066-26-8 sodium acetylide 
• 109-64-8 1,3-dibromo-propane 
• 3003-84-7 Tetrahydrofurfuryl chloride 
• 77758-50-0 4-pentynyl-1-tosylate 
• 5390-04-5 pent-1-yn-5-ol 
• 68275-03-6 pent-4-yn-1-yl methanesulfonate 

Downstream Products

• 14113-05-4 (E)-10-hydroxy-dec-2-enoic acid 
• 154188-75-7 2-(5-phenylpent-4-yn-1-yl)isoindoline-1,3-dione 
• 124620-25-3 3-propyl-2,5-diphenyl-1H-pyrrole 
• 1055262-04-8 N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridazin-6-yl)-2,2-dimethyl-N₃-(3-{1-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-1H-1,2,3-triazol-4-yl}propyl)propane-1,3-diamine 
• 1055262-88-8 N₁-(7-cyclobutyl-3-phenyl-[1,2,4]triazole[4,3-b]pyridine-6-yl)-2,2-dimethyl-N₃-(pent-4-ynyl)propane-1,3-diamine 

Relevant articles and documents

STIMULI - OR BIO- RESPONSIVE COPOLYMERS, THE POLYMERSOMES COMPRISING THE SAME AND THEIR USE IN DRUG DELIVERY

The present invention concerns amphiphilic copolymers that may be photo- or redox-cleavable and that may assemble into polymersomes. It also concerns their process of preparation and their use as drug carriers.

Product-oriented chemical surface modification of a levansucrase (SacB): Via an ene-type reaction

Carbohydrate processing enzymes are sophisticated tools of living systems that have evolved to execute specific reactions on sugars. Here we present for the first time the site-selective chemical modification of exposed tyrosine residues in SacB, a levansucrase from Bacillus megaterium (Bm-LS) for enzyme engineering purposes via an ene-type reaction. Bm-LS is unable to sustain the synthesis of high molecular weight (HMW) levan (a fructose polymer) due to protein-oligosaccharide dissociation events occurring at an early stage during polymer elongation. We switched the catalyst from levan-like oligosaccharide synthesis to the efficient production of a HMW fructan polymer through the covalent addition of a flexible chemical side-chain that fluctuates over the central binding cavity of the enzyme preventing premature oligosaccharide disengagement.

4-alkyloxyimino derivatives of uridine-5′-triphosphate: Distal modification of potent agonists as a strategy for molecular probes of P2Y 2, P2Y4, and P2Y6 receptors

Extended N4-(3-arylpropyl)oxy derivatives of uridine-5′-triphosphate were synthesized and potently stimulated phospholipase C stimulation in astrocytoma cells expressing G protein-coupled human (h) P2Y receptors (P2YRs) activated by UTP (P2Y2/4R) or UDP (P2Y6R). The potent P2Y4R-selective N4-(3- phenylpropyl)oxy agonist was phenyl ring-substituted or replaced with terminal heterocyclic or naphthyl rings with retention of P2YR potency. This broad tolerance for steric bulk in a distal region was not observed for dinucleoside tetraphosphate agonists with both nucleobases substituted. The potent N 4-(3-(4-methoxyphenyl)-propyl)oxy analogue 19 (EC50: P2Y2R, 47 nM; P2Y4R, 23 nM) was functionalized for chain extension using click tethering of fluorophores as prosthetic groups. The BODIPY 630/650 conjugate 28 (MRS4162) exhibited EC50 values of 70, 66, and 23 nM at the hP2Y2/4/6Rs, respectively, and specifically labeled cells expressing the P2Y6R. Thus, an extended N4-(3- arylpropyl)oxy group accessed a structurally permissive region on three G q-coupled P2YRs, and potency and selectivity were modulated by distal structural changes. This freedom of substitution was utilized to design of a pan-agonist fluorescent probe of a subset of uracil nucleotide-activated hP2YRs.