2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Base Information

Chemical Name:2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide
CAS No.:868524-41-8
Molecular Formula:C₂₄H₂₄Cl₂FN₃O₂
Molecular Weight:476.378
Hs Code.:

2-chloro-<i>N</i>-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Synonyms:2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

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Chemical Property of 2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

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Technology Process of 2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

There total 3 articles about 2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 868406-30-8
(E)-(5-chloro-2-{3-[3-(4-fluorobenzyl)-3,8-diazabicyclo[3.2.1]oct-8-yl]-3-oxopropenyl}phenyl)-carbamic acid tert-butyl ester

: 79-04-9
chloroacetyl chloride

: 868524-41-8
2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2005.08.057

Reference yield:

: 417727-43-6
3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]octane

: 868524-41-8
2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / EDCI*HCl; HOBt / CH₂Cl₂ / 12 h / 20 °C

2: 85 percent / tetrahydrofuran / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.057

Reference yield:

: 685534-22-9
(E)-3-(2-tert-butoxycarbonylamino-4-chlorophenyl)-acrylic acid

: 868524-41-8
2-chloro-N-(5-chloro-2-{3-[3-(4-fluoro-benzyl)-3,8-diaza-bicyclo[3.2.1]oct-8-yl]-3-oxo-propenyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / EDCI*HCl; HOBt / CH₂Cl₂ / 12 h / 20 °C

2: 85 percent / tetrahydrofuran / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.057