Technology Process of 2-(4-chlorophenyl)-2-fluoro-pentanedioic acid 1-ethyl ester
There total 4 articles about 2-(4-chlorophenyl)-2-fluoro-pentanedioic acid 1-ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H22ClFO4;
With
trifluoroacetic acid;
In
dichloromethane;
With
sodium hydrogencarbonate;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sulfuric acid / toluene / 12 h / Heating / reflux
2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 12 h / -78 °C
3.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C
3.2: 12 h / -78 - 20 °C
4.1: trifluoroacetic acid / dichloromethane
With
sulfuric acid; potassium tert-butylate; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 12 h / -78 °C
2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C
2.2: 12 h / -78 - 20 °C
3.1: trifluoroacetic acid / dichloromethane
With
potassium tert-butylate; trifluoroacetic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; dichloromethane;
