13511-29-0

Basic information

• Product Name: Ethyl (4-chlorophenyl)(hydroxy)acetate
• Synonyms: Ethyl (4-chlorophenyl)(hydroxy)acetate;ETHYL 2-(4-CHLOROPHENYL)-2-HYDROXYACETATE
• CAS NO: 13511-29-0
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.65
• Mol File: 13511-29-0.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl (4-chlorophenyl)(hydroxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (4-chlorophenyl)(hydroxy)acetate(13511-29-0)
• EPA Substance Registry System: Ethyl (4-chlorophenyl)(hydroxy)acetate(13511-29-0)

Safety Data

• Hazardous Substances Data: 13511-29-0(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 1679-18-1 4-Chlorophenylboronic acid 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 34966-48-8 ethyl 2-(4-chlorophenyl)-2-oxoacetate 
• 64-17-5 ethanol 
• 66985-46-4 (+/-)-2-(4-chlorophenyl)-2-(trimethylsiloxy)-acetonitrile 
• 7138-34-3 p-chloromandelic acid 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 34966-48-8 ethyl 2-(4-chlorophenyl)-2-oxoacetate 
• 853680-28-1 2-(4-chlorophenyl)-2-fluoro-pentanedioic acid 1-ethyl ester 
• 67593-06-0 2-(5-Chloro-2-ethoxycarbonylmethyl-phenyl)-propionic acid ethyl ester 

Relevant articles and documents

Hydroacylation of activated ketones catalyzed by N-heterocyclic carbenes

N-heterocyclic carbenes derived from triazolium salts are effective catalysts between 10 and 15 mol % for the hydroacylation of activated ketones. The reducing equivalent is generated via the interaction of a nucleophilic carbene species and an aromatic aldehyde. The subsequent alcohol product can undergo an acylation event with the resulting acyl heteroazolium intermediate formed in situ between the NHC and the aldehyde. This unprecedented multiple bond-forming reaction can accommodate aromatic aldehydes as the hydride source and various electron-deficient ketones. Preliminary mechanistic evidence indicates that the reduction and acylation steps are sequential operations. The intramolecular variant of this organocatalytic reaction affords benzofuranones in good yield. Copyright

Biocatalysed reductions of α-ketoesters employing CyreneTM as cosolvent

The search for novel reaction media with environmental friendly properties is an area of great interest in enzyme catalysis. Water is the medium of biocatalysed processes, but due to its properties, sometimes the presence of organic (co)solvents is required. CyreneTM represents one of the newest approaches to this medium engineering. This polar solvent has been employed for the first time in biocatalysed reductions employing purified alcohol dehydrogenases. A set of α-ketoesters has been reduced to the corresponding chiral α-hydroxyesters with high conversions and optical purities, being possible to obtain good results at Cyrene contents of 30% v/v and working at substrate concentrations of 1.0 M in presence of 2.5% v/v of this solvent. At this concentration, the presence of Cyrene has a beneficial effect in the bioreduction conversion.

Boron-Catalyzed O-H Bond Insertion of α-Aryl α-Diazoesters in Water

A catalytic, metal-free O-H bond insertion of α-diazoesters in water in the presence of B(C6F5)3·nH2O (2 mol %) was developed, affording a series of α-hydroxyesters in good to excellent yields. The reaction features easy operation and wide substrate scope, and importantly, no metal is needed as compared with the conventional methods. Significantly, this approach further expands the applications of B(C6F5)3 under water-tolerant conditions.