3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Base Information

Chemical Name:3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate
CAS No.:1310344-21-8
Molecular Formula:C₃₈H₅₆N₂O₆
Molecular Weight:636.872
Hs Code.:

Synonyms:3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

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Chemical Property of 3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

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Technology Process of 3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

There total 3 articles about 3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1310344-20-7
tert-butyl [20S-(dimethylamino)-16α-hydroxy-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-3β-yl]carbamate

: 93-97-0
benzoic acid anhydride

: 1310344-21-8
3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Guidance literature:: With dmap; trimethylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.02.073

Reference yield:

: N-[(3β,4α,9β,16α,20S)-20-(dimethylamino)-16-hydroxy-4-(hydroxymethyl)-4,14-dimethyl-11-oxo-9,19-cyclopregnan-3-yl]-2-methylpropanamide

: 1310344-21-8
3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / methanol

2: methanol / 5 h / 20 °C / Inert atmosphere

3: dmap; trimethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; sulfuric acid; trimethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.073

Reference yield:

: 14155-67-0
(3β,4α,9β,16α,20S)-3-amino-20-(dimethylamino)-16-hydroxy-4-(hydroxymethyl)-4,14-dimethyl-9,19-cyclopregnan-11-one

: 1310344-21-8
3β-[(tert-butoxycarbonyl)amino]-20S-(dimethylamino)-4α-(hydroxymethyl)-4β,14α-dimethyl-11-oxo-9,19-cyclo-5α,9β-pregnan-16α-yl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 5 h / 20 °C / Inert atmosphere

2: dmap; trimethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; trimethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.073