1-(Chloroacetyl)-2-methylindoline

Base Information

• Chemical Name: 1-(Chloroacetyl)-2-methylindoline
• CAS No.: 1013-18-9
• Molecular Formula: C₁₁H₁₂ClNO
• Molecular Weight: 209.675
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90408879
• Mol file: 1013-18-9.mol

Synonyms:1013-18-9;1-(chloroacetyl)-2-methylindoline;2-chloro-1-(2-methyl-2,3-dihydroindol-1-yl)ethanone;2-Chloro-1-(2-methylindolin-1-yl)ethanone;2-Chloro-1-(2-methyl-2,3-dihydro-indol-1-yl)-ethanone;2-Chloro-1-(2-methyl-2,3-dihydro-1H-indol-1-yl)ethan-1-one;SCHEMBL11438312;DTXSID90408879;Ethanone, 2-chloro-1-(2,3-dihydro-2-methyl-1H-indol-1-yl)-;MFCD03147354;AKOS000430993;AKOS016042050;SB64197;LS-04414;FT-0683817;EN300-01632;SR-01000037793;SR-01000037793-1;Z56869453;2-CHLORO-1-(2-METHYL-2,3-DIHYDRO-1H-INDOL-1-YL)-1-ETHANONE

Chemical Property of 1-(Chloroacetyl)-2-methylindoline

Chemical Property:

• Vapor Pressure: 3.78E-06mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 385.5°C at 760 mmHg
• Flash Point: 187°C
• PSA: 20.31000
• Density: 1.217g/cm³
• LogP: 2.26800
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 209.0607417
• Heavy Atom Count: 14
• Complexity: 231

Purity/Quality:

97% ^*data from raw suppliers

1-(Chloroacetyl)-2-methylindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2=CC=CC=C2N1C(=O)CCl

Technology Process of 1-(Chloroacetyl)-2-methylindoline

There total 2 articles about 1-(Chloroacetyl)-2-methylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetyl chloride (79-04-9) + 2-methyl indoline (6872-06-6) → 1-(chloroacetyl)-2-methylindoline (1013-18-9)

Guidance literature:

With TEA; In chloroform; at 20 ℃; for 18h;

DOI:10.1016/S0960-894X(02)00655-8

Reference yield:

→ 1-(chloroacetyl)-2-methylindoline (1013-18-9)

Guidance literature:

aus 2-Methyl-2,3-dihydro-indol, Chloracetylchlorid;

Reference yield:

1-(chloroacetyl)-2-methylindoline (1013-18-9) + C11H9ClN2O3 (1421365-17-4) → C22H20ClN3O4 (1421365-64-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2012.12.030

upstream raw materials:

chloroacetyl chloride

2-methyl indoline