2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide

Base Information

• Chemical Name: 2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide
• CAS No.: 276681-96-0
• Molecular Formula: C₂₁H₂₇N₃O₅S
• Molecular Weight: 433.528
• Mol file: 276681-96-0.mol

Synonyms:2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide

Chemical Property of 2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide

There total 1 articles about 2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

BOC-glycine (4530-20-5) + 3-amino-N-(2,3-dimethylphenylbenzene sulphonamide) (244013-66-9) → 2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide (276681-96-0)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -15 - 20 ℃;

DOI:10.1211/146080800128735746

Reference yield:

2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide (276681-96-0) → 2-amino-N-[3-(2,3-dimethyl-phenylsulfamoyl)-phenyl]-acetamide

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1211/146080800128735746

Reference yield:

2-(tert-butyloxycarbonylamino)-N-[3-(2,3-dimethylphenylaminosulphonyl)phenyl]acetic acid amide (276681-96-0) → N-{[3-(2,3-dimethylphenylaminosulphonyl)phenylaminocarbonyl]methyl}heptadecanoic acid amide

Guidance literature:

Multi-step reaction with 2 steps

1: HCl (gas) / dioxane / 2 h / 20 °C

2: 91 percent / N-methylmorpholine; isobutyl chloroformate / dimethylformamide / -15 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1211/146080800128735746

upstream raw materials:

BOC-glycine

3-amino-N-(2,3-dimethylphenylbenzene sulphonamide)