LNK 131

Base Information

• Chemical Name: LNK 131
• CAS No.: 748724-48-3
• Molecular Formula: C₁₆H₁₅Cl₂N
• Molecular Weight: 292.208
• Mol file: 748724-48-3.mol

Synonyms:LNK 131

Chemical Property of LNK 131

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of LNK 131

There total 11 articles about LNK 131 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylamine hydrochloride (593-51-1) + 3-(3',4'-dichlorophenyl)-indan-1-one (85662-98-2,80272-27-1) → LNK 131 (748724-48-3,86939-10-8)

Guidance literature:

With titanium(IV) isopropylate; sodium cyanoborohydride; In methanol; at 40 ℃; Inert atmosphere;

Reference yield:

C16H13Cl2N → LNK 131 (748724-48-3,86939-10-8)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃;

Reference yield:

3-(3',4'-dichlorophenyl)-3-phenylpropanoic acid (80272-06-6) → LNK 131 (748724-48-3,86939-10-8)

Guidance literature:

Multi-step reaction with 3 steps

1: chlorosulfonic acid / dichloromethane / 20 °C

2: methanol / 2.5 h / 20 °C

3: sodium tetrahydroborate; methanol / 20 °C

With methanol; chlorosulfonic acid; sodium tetrahydroborate; In methanol; dichloromethane;

upstream raw materials:

benzaldehyde

benzene

3-(3',4'-dichlorophenyl)-3-phenylpropanoic acid

3-(3',4'-dichlorophenyl)-indan-1-one

Downstream raw materials:

LNK 131 hydrochloride

C₁₆H₁₅Cl₂N*ClH

Refernces

• 1、 -. "TREATMENT OF NEURODEGENERATIVE DISEASES USING INDATRALINE ANALOGS". . . Retrieved 2009/04/25.