1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide

Base Information

• Chemical Name: 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide
• CAS No.: 349629-96-5
• Molecular Formula: C₁₂H₁₃N₅OS
• Molecular Weight: 275.334
• Mol file: 349629-96-5.mol

Synonyms:1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide

Chemical Property of 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide

There total 2 articles about 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

phenyl isothiocyanate (103-72-0) + 5-methyl-1H-imidazole-4-carboxylic acid hydrazide (71704-67-1) → 1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide (349629-96-5)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.ejmech.2010.05.017

Reference yield: 62.0%

phenyl isothiocyanate (103-72-0) + 4-methylimidazol-5-yl-carboxylic acid hydrazide (71704-67-1) → 1-(4-methylimidazol-5-yl-carbonyl)-4-phenylthiosemicarbazide (349629-96-5)

Guidance literature:

In diethyl ether; at 80 ℃; for 12h;

DOI:10.1002/hc.20643

Reference yield: 93.0%

1-[(5-methyl-1H-imidazole-4-yl)carbonyl]-4-phenylthiosemicarbazide (349629-96-5) → N-phenyl-5-(5-methyl-1H-imidazole-4-yl)-1,3,4-thiadiazole-2-amine (1246611-22-2)

Guidance literature:

With sulfuric acid; at 50 ℃; for 2h;

DOI:10.1016/j.ejmech.2010.05.017

upstream raw materials:

phenyl isothiocyanate

5-methyl-1H-imidazole-4-carboxylic acid hydrazide

4-methylimidazol-5-yl-carboxylic acid hydrazide

Downstream raw materials:

3-phenyl-2-[(5-methyl-1H-imidazole-4-yl)carbonyl]hydrazono-4-oxo-1,3-thiazolidin-5-yl-acetic acid

N-phenyl-5-(5-methyl-1H-imidazole-4-yl)-1,3,4-thiadiazole-2-amine

5-(4-methylimidazol-5-yl)-4-phenyl-s-triazole-3-thione