N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

Base Information

Chemical Name:N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester
CAS No.:889849-75-6
Molecular Formula:C₁₉H₂₁ClN₂O₃
Molecular Weight:360.84
Hs Code.:

<i>N</i>-(4-chloro-phenyl)-<i>N</i>-pyridin-2-ylmethyl-malonamic acid <i>tert</i>-butyl ester

Synonyms:N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

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Chemical Property of N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

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Technology Process of N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

There total 3 articles about N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 27048-28-8
4-chloro-N-(pyridin-2-ylmethyl)aniline

: 889849-75-6
N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 3h;
DOI:10.1016/j.bmcl.2006.02.044

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 889849-75-6
N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH(OAc)3; AcOH / CH₂Cl₂ / 3 h / 25 °C

2: EDCI / CH₂Cl₂ / 3 h / 25 °C

With sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2006.02.044

Reference yield:

: 106-47-8
4-chloro-aniline

: 889849-75-6
N-(4-chloro-phenyl)-N-pyridin-2-ylmethyl-malonamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH(OAc)3; AcOH / CH₂Cl₂ / 3 h / 25 °C

2: EDCI / CH₂Cl₂ / 3 h / 25 °C

With sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmcl.2006.02.044