N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

Base Information

Chemical Name:N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide
CAS No.:1394897-92-7
Molecular Formula:C₂₃H₂₈N₂O₃S
Molecular Weight:412.553
Hs Code.:

Synonyms:N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

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Chemical Property of N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

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Technology Process of N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

There total 3 articles about N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394897-90-5
C₂₃H₂₆N₂O₂S

: 1394897-92-7
N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

Guidance literature:: With water; for 730.5h; Storing conditions; Neat (no solvent);
DOI:10.1016/j.tetasy.2012.06.016

Reference yield:

: 1003-31-2
thiophene-2-carbonitrile

: 1394897-92-7
N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water

2.1: acetic acid; triethylamine / dichloromethane / 24 h / 25 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 3 h / 0 - 25 °C / Inert atmosphere

4.1: water / 730.5 h / Storing conditions; Neat (no solvent)

With hydrogenchloride; water; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; 1.1: Pinner amidine synthesis;
DOI:10.1016/j.tetasy.2012.06.016

Reference yield:

: 1394897-76-7
(1S,2R,6S,7R)-7,10,10-trimethyl-4-(thiophen-2-yl)-3,5-diazatricyclo[5.2.1.0(2,6)]dec-3-ene

: 100-07-2
4-methoxy-benzoyl chloride

: 1394897-92-7
N-[(1S,2R,3S,4R)-3-(4-methoxybenzoylamino)-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thiophene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 25 °C / Inert atmosphere

2.1: water / 730.5 h / Storing conditions; Neat (no solvent)

With water; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2012.06.016