{4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

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Chemical Name:{4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester
CAS No.:898552-50-6
Molecular Formula:C₂₆H₂₈ClN₃O₅S
Molecular Weight:530.044
Hs Code.:

Synonyms:{4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

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Chemical Property of {4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

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Technology Process of {4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

There total 10 articles about {4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 898552-43-7
4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester

: 6456-74-2
Glycine tert-butyl ester

: 898552-50-6
{4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

Guidance literature:: In chloroform; for 6h;

Reference yield:

: 898552-72-2
ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride

: 898552-50-6
{4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

2: potassium carbonate / 6 h / 120 °C

3: trifluoroacetic acid / water / 16 h / 90 °C

4: dmap; triethylamine / dichloromethane / 16 h / 25 °C

5: chloroform / 6 h

With dmap; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; chloroform; water;

Reference yield:

: 130912-54-8
3,3-dimethyl-4-nitro-butyric acid ethyl ester

: 898552-50-6
{4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyrylamino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 110 °C / 3344.22 Torr

2: hydrogenchloride; water / 20 h / 120 °C

3: ethanol / 16 h / 85 °C / Heating / reflux

4: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

5: potassium carbonate / 6 h / 120 °C

6: trifluoroacetic acid / water / 16 h / 90 °C

7: dmap; triethylamine / dichloromethane / 16 h / 25 °C

8: chloroform / 6 h

With hydrogenchloride; dmap; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; chloroform; water;