(+)-2-phenyl-1-phthalimidobutane

Base Information

• Chemical Name: (+)-2-phenyl-1-phthalimidobutane
• CAS No.: 77738-68-2
• Molecular Formula: C₁₈H₁₇NO₂
• Molecular Weight: 279.338
• Mol file: 77738-68-2.mol

Synonyms:(+)-2-phenyl-1-phthalimidobutane

Chemical Property of (+)-2-phenyl-1-phthalimidobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-2-phenyl-1-phthalimidobutane

There total 8 articles about (+)-2-phenyl-1-phthalimidobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(+)-3,3-ethylenedithio-2-phenyl-1-phthalimidobutane (77738-67-1) → (+)-2-phenyl-1-phthalimidobutane (77738-68-2)

Guidance literature:

Raney nickel (W-1 activity); In acetone; for 6h; Heating;

DOI:10.1039/P19810000906

Reference yield:

phthalic anhydride (85-44-9) → (+)-2-phenyl-1-phthalimidobutane (77738-68-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 85 percent / triethylamine / toluene / 5 h / Heating

2: 97 percent / thionyl chloride / 5 h / Heating

3: 90 percent / diethyl ether; benzene / 12 h / 20 °C

4: 85 percent / 67percent hydriodic acid / CHCl₃ / 0.33 h / -5 °C

5: 81 percent / boron trifluoride-ether / diethyl ether / 1.) -10 deg C, 1 h, 2.) room temperature, 3 days

6: 85 percent / Raney nickel (W-1 activity) / acetone / 6 h / Heating

With thionyl chloride; boron trifluoride diethyl etherate; hydrogen iodide; triethylamine; Raney nickel (W-1 activity); In diethyl ether; chloroform; acetone; toluene; benzene;

DOI:10.1039/P19810000906

Reference yield:

2-phenylacrylic acid (492-38-6) → (+)-2-phenyl-1-phthalimidobutane (77738-68-2)

Guidance literature:

Multi-step reaction with 7 steps

2: 85 percent / triethylamine / toluene / 5 h / Heating

3: 97 percent / thionyl chloride / 5 h / Heating

4: 90 percent / diethyl ether; benzene / 12 h / 20 °C

5: 85 percent / 67percent hydriodic acid / CHCl₃ / 0.33 h / -5 °C

6: 81 percent / boron trifluoride-ether / diethyl ether / 1.) -10 deg C, 1 h, 2.) room temperature, 3 days

7: 85 percent / Raney nickel (W-1 activity) / acetone / 6 h / Heating

With thionyl chloride; boron trifluoride diethyl etherate; hydrogen iodide; triethylamine; Raney nickel (W-1 activity); In diethyl ether; chloroform; acetone; toluene; benzene;

DOI:10.1039/P19810000906

upstream raw materials:

(+)-3,3-ethylenedithio-2-phenyl-1-phthalimidobutane

phthalic anhydride

2-phenylacrylic acid

(S)-3-amino-2-phenylpropanoic acid

Downstream raw materials:

(+)-1-amino-2-phenylbutane

Refernces