(4-Methoxybenzyl)hydrazine

Base Information

• Chemical Name: (4-Methoxybenzyl)hydrazine
• CAS No.: 140-69-2
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.196
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID30274570
• Nikkaji Number: J238.968A
• Wikidata: Q72489275
• Mol file: 140-69-2.mol

Synonyms:(4-methoxybenzyl)hydrazine;140-69-2;(4-methoxyphenyl)methylhydrazine;4-methoxybenzylhydrazine;[(4-methoxyphenyl)methyl]hydrazine;hydrazine, [(4-methoxyphenyl)methyl]-;(4-Methoxybenzyl)Hydrazinedihydrochloride;MFCD07786530;4-METHOXY-BENZYL-HYDRAZINE;Hydrazine,[(4-methoxyphenyl)methyl]-;4-methoxybenzyl hydrazine;para-methoxybenzylhydrazine;1-(4-Methoxybenzyl)hydrazine;SCHEMBL366364;DTXSID30274570;STL163524;AKOS000153765;SB10048;AMY202003301;SY025460;BB 0219963;FT-0649608;EN300-44108

Chemical Property of (4-Methoxybenzyl)hydrazine

Chemical Property:

• Vapor Pressure: 7.4E-06mmHg at 25°C
• Melting Point: 34-36 °C
• Boiling Point: 311.9 °C at 760 mmHg
• PKA: 7.46±0.70(Predicted)
• Flash Point: 142.5 °C
• PSA: 47.28000
• Density: 1.069 g/cm³
• LogP: 3.35370
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 152.094963011
• Heavy Atom Count: 11
• Complexity: 100

Purity/Quality:

97% ^*data from raw suppliers

(4-Methoxybenzyl)hydrazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CNN

Technology Process of (4-Methoxybenzyl)hydrazine

There total 7 articles about (4-Methoxybenzyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

p-methoxybenzyl chloride (824-94-2) → 4-methoxybenzylhydrazine (140-69-2)

Guidance literature:

With potassium carbonate; hydrazine hydrate; at 10 - 30 ℃; Inert atmosphere;

DOI:10.1055/s-0034-1379974

Reference yield: 65.0%

2-((4-methoxybenzyl)amino)isoindoline-1,3-dione (345928-21-4) → 2,3-dihydrophthalazine-1,4-dione (1445-69-8) + 4-methoxybenzylhydrazine (140-69-2)

Guidance literature:

With hydrazine hydrate; In ethanol; water; Heating;

Reference yield:

N-(p-methoxybenzylidene)aminophthalimide (85468-48-0) → 4-methoxybenzylhydrazine (140-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / hydrogen, / 5percent palladium on charcoal / dimethylformamide / 20 h / 2585.7 Torr

2: 65 percent / 64percent NH₂NH₂*H₂O / H₂O; ethanol / 2.5 h / Heating

With hydrogen; hydrazine hydrate; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

p-anisaldehyde hydrazone

p-methoxybenzyl chloride

4-methoxy-benzaldehyde-(4-methoxy-benzylhydrazone)

2-((4-methoxybenzyl)amino)isoindoline-1,3-dione

Downstream raw materials:

1-(p-methoxyphenyl)methyl-pyrazole

(+/-)-3-(4-methoxybenzyl)-3,4-diazabicyclo[4.1.0]heptane-2,5-dione

ethyl 5-hydroxy-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylate

2-(4-methoxybenzyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one