{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

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Chemical Name:{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane
CAS No.:251083-06-4
Molecular Formula:C₃₉H₆₈O₆S₂Si
Molecular Weight:725.183
Hs Code.:

{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

Synonyms:{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

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Chemical Property of {(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

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Technology Process of {(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

There total 15 articles about {(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 251083-19-9
C₃₀H₄₈O₆S₂

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 251083-06-4
{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

Guidance literature:: With 2,6-dimethylpyridine;
DOI:10.1021/ol9909233

Reference yield:

: 251083-18-8
2-((S)-1-Methyl-but-2-ynyl)-[1,3]dithiane

: 251083-06-4
{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₃SnH / PdCl₂(PPh₃)2

1.2: 79 percent / I₂ / CH₂Cl₂ / 0 °C

2.1: t-BuLi / diethyl ether; pentane / 0.42 h / -78 °C

2.2: diethyl ether; pentane / -100 - -78 °C

3.1: 89 percent / 2,6-lutidine

With 2,6-dimethylpyridine; tert.-butyl lithium; tri-n-butyl-tin hydride; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; pentane;
DOI:10.1021/ol9909233

Reference yield:

: 251083-17-7
C₈H₁₂S₂Br₂

: 251083-06-4
{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 64 percent / n-BuLi / methanol

2.1: 91 percent / t-BuLi

3.1: Bu₃SnH / PdCl₂(PPh₃)2

3.2: 79 percent / I₂ / CH₂Cl₂ / 0 °C

4.1: t-BuLi / diethyl ether; pentane / 0.42 h / -78 °C

4.2: diethyl ether; pentane / -100 - -78 °C

5.1: 89 percent / 2,6-lutidine

With 2,6-dimethylpyridine; n-butyllithium; tert.-butyl lithium; tri-n-butyl-tin hydride; bis-triphenylphosphine-palladium(II) chloride; In methanol; diethyl ether; pentane;
DOI:10.1021/ol9909233