(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

Base Information

Chemical Name:(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol
CAS No.:777096-29-4
Molecular Formula:C₃₆H₆₄O₆S₂Si
Molecular Weight:685.118
Hs Code.:

Synonyms:(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

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Chemical Property of (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

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Technology Process of (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

There total 1 articles about (E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 251083-06-4
{(E)-(1R,4S)-1-[(1S,2R,3R,4S)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-methoxy-2-(4-methoxy-benzyloxy)-1,3-dimethyl-butyl]-4-[1,3]dithian-2-yl-2-methyl-pent-2-enyloxy}-triisopropyl-silane

: 777096-29-4
(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol;
DOI:10.1021/ja0289649

Reference yield:

: 777096-29-4
(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

: 777096-56-7
C₆₈H₁₂₄O₁₀S₂Si₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,4,6-collidine / -78 °C

2.1: TBAI; DIEA / CH₂Cl₂

3.1: K₂CO₃ / methanol

4.1: t-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.07 h / -78 °C

4.2: 75 percent / tetrahydrofuran / 0.17 h

5.1: SO₃*pyr; DMSO

With 2,4,6-trimethyl-pyridine; pyridine-SO₃ complex; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; potassium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 5.1: Parikh-Doering oxidation;
DOI:10.1021/ja0289649

Reference yield:

: 777096-29-4
(E)-(2S,3S,4R,5R,6S,7R,10S)-10-[1,3]Dithian-2-yl-3-methoxy-5-(4-methoxy-benzyloxy)-4,6,8-trimethyl-7-triisopropylsilanyloxy-undec-8-ene-1,2-diol

: 777096-34-1
C₆₈H₁₂₆O₁₀S₂Si₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-collidine / -78 °C

2.1: TBAI; DIEA / CH₂Cl₂

3.1: K₂CO₃ / methanol

4.1: t-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.07 h / -78 °C

4.2: 75 percent / tetrahydrofuran / 0.17 h

With 2,4,6-trimethyl-pyridine; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/ja0289649