4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Base Information

Chemical Name:4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile
CAS No.:1335330-79-4
Molecular Formula:C₁₇H₁₄ClN₅OS
Molecular Weight:371.85
Hs Code.:

Synonyms:4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

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Chemical Property of 4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

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Technology Process of 4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

There total 8 articles about 4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1335330-84-1
(E)-3-(4-chlorophenyl)-4-cyano-N-((dimethylamino)methylene)-5-(morpholin-4-yl)thiophene-2-carboxamide

: 1335330-79-4
4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Guidance literature:: With hydrazine hydrate; acetic acid; In ethanol; at 20 - 60 ℃; for 2h;
DOI:10.1021/ml200126j

Reference yield:

: 4-cyano-3-iodo-5-(methylthio)thiophene-2-carboxylic acid ethyl ester

: 1335330-79-4
4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / DCE; ethanol / 16 h / Inert atmosphere; Reflux

3.1: water; sodium hydroxide / tetrahydrofuran; ethanol / 20 °C

3.2: pH 6

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.1: ammonia / diethyl ether

6.1: 1.5 h / 110 °C

7.1: hydrazine hydrate; acetic acid / ethanol / 2 h / 20 - 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; ammonia; water; potassium carbonate; hydrazine hydrate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; DCE; diethyl ether; ethanol; dichloromethane; 2.1: Suzuki coupling;
DOI:10.1021/ml200126j

Reference yield:

: C₁₆H₁₂Cl₂N₂O₂S

: 1335330-79-4
4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / diethyl ether

2: 1.5 h / 110 °C

3: hydrazine hydrate; acetic acid / ethanol / 2 h / 20 - 60 °C

With ammonia; hydrazine hydrate; acetic acid; In diethyl ether; ethanol;
DOI:10.1021/ml200126j