ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate

Base Information

• Chemical Name: ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate
• CAS No.: 1184915-94-3
• Molecular Formula: C₁₈H₁₇ClN₂O₃S
• Molecular Weight: 376.864
• Mol file: 1184915-94-3.mol

Synonyms:ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate

Chemical Property of ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate

There total 2 articles about ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-cyano-3-iodo-5-(morpholin-4-yl)thiophene-2-carboxylic acid ethyl ester (1276553-18-4) + 4-Chlorophenylboronic acid (1679-18-1) → ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate (1184915-94-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In DCE; ethanol; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/ml200126j

Reference yield:

4-cyano-3-iodo-5-(methylthio)thiophene-2-carboxylic acid ethyl ester → ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate (1184915-94-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / DCE; ethanol / 16 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In DCE; ethanol; dichloromethane; 2.1: Suzuki coupling;

DOI:10.1021/ml200126j

Reference yield: 95.0%

ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate (1184915-94-3) → 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylic acid (883097-33-4)

Guidance literature:

ethyl 3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃;

With acetic acid; In water; pH=6;

DOI:10.1021/ml200126j

upstream raw materials:

4-cyano-3-iodo-5-(morpholin-4-yl)thiophene-2-carboxylic acid ethyl ester

4-Chlorophenylboronic acid

Downstream raw materials:

3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxylic acid

3-(4-chlorophenyl)-4-cyano-5-(morpholin-4-yl)thiophene-2-carboxamide

(E)-3-(4-chlorophenyl)-4-cyano-N-((dimethylamino)methylene)-5-(morpholin-4-yl)thiophene-2-carboxamide

4-(4-chlorophenyl)-2-(morpholin-4-yl)-5-(1H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile