4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

Base Information

Chemical Name:4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide
CAS No.:1310816-21-7
Molecular Formula:C₂₃H₂₁ClN₄O₂
Molecular Weight:420.898
Hs Code.:

Synonyms:4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

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Chemical Property of 4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

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Technology Process of 4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

There total 22 articles about 4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.58%

: 1140517-90-3
1-[(4-chlorobenzoyl)amino]cyclopropanecarboxylic acid

: 1310816-97-7
(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-amine

: 1310816-21-7
4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; at -20 - 20 ℃; Product distribution / selectivity;

Reference yield: 80.0%

: 1310817-20-9
1-amino-N-[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]cyclopropanecarboxamide

: 74-11-3
para-chlorobenzoic acid

: 1310816-21-7
4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

Reference yield:

: 145485-03-6
((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamic acid tert-butyl ester

: 1310816-21-7
4-Chloro-N-[1-[[(4R)-5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl]carbamoyl]cyclopropyl]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride; water / methanol / 1 h

2.1: sodium carbonate / water; acetonitrile / 4 h / 20 °C

3.1: Lawessons reagent / toluene / 2.5 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / dichloromethane / 49 h / 20 °C / Industry scale

5.1: formic acid / 1.33 h / 95 °C / Industry scale

5.2: pH 7

5.3: Chiralpak AD (20 micron) column

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 7 h / 20 °C / 3102.97 Torr / Parr shaker

7.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane / -20 - 20 °C

With Lawessons reagent; hydrogenchloride; formic acid; water; hydrogen; sodium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; dichloromethane; water; toluene; acetonitrile;